| OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec |
| vsNew York | W32-19 | 1-0 | Purdy 231 | Mason 147 | Jennings 64 |
| @Minnesota | L23-17 | 1-1 | Purdy 319 | Mason 100 | Samuel Sr. 110 |
| @Los Angeles | L27-24 | 1-2 | Purdy 292 | Mason 77 | Jennings 175 |
| vsNew England | W30-13 | 2-2 | Purdy 288 | Mason 123 | Jennings 88 |
| vsArizona | L24-23 | 2-3 | Purdy 244 | Mason 89 | Aiyuk 147 |
| @Seattle | W36-24 | 3-3 | Purdy 255 | Guerendo 99 | Samuel Sr. 102 |
| vsKansas City | L28-18 | 3-4 | Purdy 212 | Mason 58 | Kittle 92 |
| vsDallas | W30-24 | 4-4 | Purdy 260 | Guerendo 85 | Kittle 128 |
| @Tampa Bay | W23-20 | 5-4 | Purdy 353 | McCaffrey 39 | Jennings 93 |
| vsSeattle | L20-17 | 5-5 | Purdy 159 | McCaffrey 79 | Jennings 91 |
| OPPONENT | TIME | TV | tickets | ||
| @Green Bay | 2:25 PM | FOX | Tickets as low as $127 | ||
| @Buffalo | 6:20 PM | NBCPeacock | Tickets as low as $159 | ||
| vsChicago | 2:25 PM | FOX | Tickets as low as $139 | ||
| vsLos Angeles | 6:15 PM | Prime Video | Tickets as low as $90 | ||
| @Miami | 2:25 PM | CBS | Tickets as low as $115 | ||
| vsDetroit | 6:15 PM | Tickets as low as $185 | |||
| @Arizona | TBD | Tickets as low as $109 | |||